When you first get your braces on, you may feel general discomfort in your mouth and teeth may be tender when biting down for three to five days. Your cheeks, tongue, and lips may also feel sore and raw from the new hardware. The good news is that usually in two to three weeks the soft tissues toughen up and the irritation will go away. You can use the orthodontic wax on the parts that feel irritating, or a mild salt water rinse (one teaspoon of salt in 8 ounces of warm water, 3-4 times a day) will also help the healing. If the tenderness is severe, take aspirin or whatever you normally take for headaches or similar pain.